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Comstock, Laurie
One or more keywords matched the following properties of Comstock, Laurie
PropertyValue
keywords Bacterial interactions
keywords Bacterial antagonism
overview The human intestinal microbiota is a complex and dynamic consortium of microbes that is crucial for human health and disease prevention. Our lab has been studying the abundant bacterial members of this ecosystem to understand how they interact with each other both cooperatively and antagonistically to form these health-promoting communities. We use basic microbiological, genetic, biochemical, and gnotobiotic mouse analyses, combined with genomic, metagenomic and computational analyses to understand these complex interactions. We have discovered numerous classes of new antimicrobial proteins that these bacteria use to compete in their ecosystem, and we are studying their mechanisms of action, ecological properties, and how we may translate these molecules for human health benefits. Another focus of the lab is the evolution of microbes in the human gut and how genetic elements horizontally transferred between bacterial species personalize each individual’s gut microbiota and the phenotypes and community benefits conferred by these shared genetic elements.
One or more keywords matched the following items that are connected to Comstock, Laurie
Item TypeName
Concept Antibodies, Bacterial
Concept Antigens, Bacterial
Concept Bacterial Adhesion
Concept Bacterial Infections
Concept Bacterial Outer Membrane Proteins
Concept Bacterial Toxins
Concept Bacterial Proteins
Concept Bacterial Vaccines
Concept Chromosomes, Bacterial
Concept DNA, Bacterial
Concept Genes, Bacterial
Concept Fimbriae, Bacterial
Concept RNA, Bacterial
Concept Genome, Bacterial
Concept Vaginosis, Bacterial
Concept Gram-Negative Bacterial Infections
Concept Drug Resistance, Multiple, Bacterial
Concept Drug Resistance, Bacterial
Concept Polysaccharides, Bacterial
Concept Bacterial Capsules
Concept Bacterial Secretion Systems
Concept Anti-Bacterial Agents
Concept Gene Expression Regulation, Bacterial
Academic Article Bacterial glycans: key mediators of diverse host immune responses.
Academic Article Gut Symbiont Bacteroides fragilis Secretes a Eukaryotic-Like Ubiquitin Protein That Mediates Intraspecies Antagonism.
Academic Article Expression of phase variable surface molecules of Bacteroides species from healthy and clinical stool.
Academic Article A family of anti-Bacteroidales peptide toxins wide-spread in the human gut microbiota.
Academic Article Immunochemical and biological characterization of three capsular polysaccharides from a single Bacteroides fragilis strain.
Academic Article Theoretical and experimental characterization of the scope of protein O-glycosylation in Bacteroides fragilis.
Academic Article Type VI Secretion Systems and the Gut Microbiota.
Academic Article Friend turned foe: a role for bacterial sulfatases in colitis.
Academic Article Type VI secretion systems of human gut Bacteroidales segregate into three genetic architectures, two of which are contained on mobile genetic elements.
Academic Article Bacteroides fragilis synthesizes a DNA invertase affecting both a local and a distant region.
Academic Article Streamlined Genetic Manipulation of Diverse Bacteroides and Parabacteroides Isolates from the Human Gut Microbiota.
Academic Article Analysis of a capsular polysaccharide biosynthesis locus of Bacteroides fragilis.
Academic Article Phase-variable expression of a family of glycoproteins imparts a dynamic surface to a symbiont in its human intestinal ecosystem.
Academic Article UDP-glucuronic acid decarboxylases of Bacteroides fragilis and their prevalence in bacteria.
Academic Article Evidence of extensive DNA transfer between bacteroidales species within the human gut.
Academic Article Interstrain variation of the polysaccharide B biosynthesis locus of Bacteroides fragilis: characterization of the region from strain 638R.
Academic Article Bacteroides fragilis type VI secretion systems use novel effector and immunity proteins to antagonize human gut Bacteroidales species.
Academic Article Orientations of the Bacteroides fragilis capsular polysaccharide biosynthesis locus promoters during symbiosis and infection.
Academic Article Nanaerobic growth enables direct visualization of dynamic cellular processes in human gut symbionts.
Academic Article A New Pillar in Pilus Assembly.
Academic Article Human symbionts use a host-like pathway for surface fucosylation.
Academic Article Identification of a Fifth Antibacterial Toxin Produced by a Single Bacteroides fragilis Strain.
Academic Article Phylum-wide general protein O-glycosylation system of the Bacteroidetes.
Academic Article Expression of a uniquely regulated extracellular polysaccharide confers a large-capsule phenotype to Bacteroides fragilis.
Academic Article A family of transcriptional antitermination factors necessary for synthesis of the capsular polysaccharides of Bacteroides fragilis.
Academic Article A defined O-antigen polysaccharide mutant of Francisella tularensis live vaccine strain has attenuated virulence while retaining its protective capacity.
Academic Article Bacteroides fragilis NCTC9343 produces at least three distinct capsular polysaccharides: cloning, characterization, and reassignment of polysaccharide B and C biosynthesis loci.
Academic Article Genetic diversity of the capsular polysaccharide C biosynthesis region of Bacteroides fragilis.
Academic Article Small RNAs Repress Expression of Polysaccharide Utilization Loci of Gut Bacteroides Species.
Academic Article Polysaccharide biosynthesis locus required for virulence of Bacteroides fragilis.
Academic Article Role of glycan synthesis in colonization of the mammalian gut by the bacterial symbiont Bacteroides fragilis.
Academic Article Trans locus inhibitors limit concomitant polysaccharide synthesis in the human gut symbiont Bacteroides fragilis.
Academic Article Extensive surface diversity of a commensal microorganism by multiple DNA inversions.
Academic Article Bacterial antagonism in host-associated microbial communities.
Academic Article Acquisition of MACPF domain-encoding genes is the main contributor to LPS glycan diversity in gut Bacteroides species.
Academic Article Niche-specific features of the intestinal bacteroidales.
Academic Article Mobile Type VI secretion system loci of the gut Bacteroidales display extensive intra-ecosystem transfer, multi-species spread and geographical clustering.
Academic Article Bacteroidales Secreted Antimicrobial Proteins Target Surface Molecules Necessary for Gut Colonization and Mediate Competition In Vivo.
Academic Article An antimicrobial protein of the gut symbiont Bacteroides fragilis with a MACPF domain of host immune proteins.
Academic Article Analysis of a phase-variable restriction modification system of the human gut symbiont Bacteroides fragilis.
Academic Article "Cross-glycosylation" of proteins in Bacteroidales species.
Academic Article Longitudinal analysis of the prevalence, maintenance, and IgA response to species of the order Bacteroidales in the human gut.
Academic Article Tyrosine site-specific recombinases mediate DNA inversions affecting the expression of outer surface proteins of Bacteroides fragilis.
Academic Article Mpi recombinase globally modulates the surface architecture of a human commensal bacterium.
Academic Article The capsule and O antigen in Vibrio cholerae O139 Bengal are associated with a genetic region not present in Vibrio cholerae O1.
Academic Article Interaction of Lyme disease spirochetes with cultured eucaryotic cells.
Academic Article The evolution of tit-for-tat in bacteria via the type VI secretion system.
Academic Article A monoclonal antibody to OspA inhibits association of Borrelia burgdorferi with human endothelial cells.
Academic Article Characterization of Borrelia burgdorferi invasion of cultured endothelial cells.
Academic Article Genetic and Biochemical Analysis of Anaerobic Respiration in Bacteroides fragilis and Its Importance In Vivo.
Academic Article A general O-glycosylation system important to the physiology of a major human intestinal symbiont.
Academic Article Vibriocidal antibody responses in North American volunteers exposed to wild-type or vaccine Vibrio cholerae O139: specificity and relevance to immunity.
Academic Article Cloning and sequence of a region encoding a surface polysaccharide of Vibrio cholerae O139 and characterization of the insertion site in the chromosome of Vibrio cholerae O1.
Academic Article Distribution of Zonula occludens toxin (zot) gene among clinical isolates of Vibrio cholerae O1 from Bangladesh and Africa.
Academic Article Initial clinical studies of CVD 112 Vibrio cholerae O139 live oral vaccine: safety and efficacy against experimental challenge.
Academic Article Bacteroidetocins Target the Essential Outer Membrane Protein BamA of Bacteroidales Symbionts and Pathogens.
Academic Article A Combination of Structural, Genetic, Phenotypic and Enzymatic Analyses Reveals the Importance of a Predicted Fucosyltransferase to Protein O-Glycosylation in the Bacteroidetes.
Academic Article Analysis of Effector and Immunity Proteins of the GA2 Type VI Secretion Systems of Gut Bacteroidales.
Academic Article A proteolytically activated antimicrobial toxin encoded on a mobile plasmid of Bacteroidales induces a protective response.
Academic Article A ubiquitous mobile genetic element disarms a bacterial antagonist of the gut microbiota.
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  • Bacterial
  • Pathogenesis